Table VII.
Yield, Loading and Dissolution Behavior of Paclitaxel Nanoparticle Agglomerates (Values=Average±S.D.)
| Characteristics | Formulations
|
||
|---|---|---|---|
| F1a | F2b | F1 Combc | |
| Process yield of lyophilized NAd | 86±3% | 90±3% | 89±2% |
| % Drug loading of PX and CP in the lyophilized NAd | 85±4% | 86±9% | 93±4% (PX) 90±5% (CP) |
| Q8hf NPe | 66±2% | 61±13% | n/a |
| Q8hf NAd | 44±4% | 40±3% | 61±5% (PX) 100±2% (CP) |
F1=0.1:0.02:0.01; PX:Lec:PVP K90
F2=0.1:0.02; PX:Lec
F1 Comb=3:2; PX:CP
NA: nanoparticle agglomerates
NP: nanoparticles
Q8h: % Paclitaxel (PX) and cisplatin (CP) dissolved after 8 h