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. Author manuscript; available in PMC: 2015 Apr 10.
Published in final edited form as: Cell. 2014 Apr 10;157(2):357–368. doi: 10.1016/j.cell.2014.02.053

Figure 2. TCR forms agonist-specific catch-slip bond.

Figure 2

(A) Lifetimes of bonds of OT1 T-cells with probe beads coated with indicated pMHCs at 0 (white) and 10 (black) pN. (B and C) Lifetime vs. force curves showing that OT1 TCR formed catch-slip bonds with progressively weaker agonists OVA (red open square), A2 (light blue open triangle), and G4 (inverted magenta open triangle) (B) but slip-only bonds with antagonists R4 (blue open circle) and E1 (green open diamond) (C). (D) Force regulation of antigen discrimination, measured by the average lifetime ratio of TCR bonds with OVA to another peptide. See also Figure S2.