Table 6.
“Bio-imaging” studies using coronary computed tomography and biomarkers in stable CAD patients.
| Bio-markers | CT Imaging technique | Number of patients | Main result/ conclusion | |
|---|---|---|---|---|
| Laufer et al., 2010 | hsTnT | 64-slice CT | 615 | HsTnT strongly is associated with CAD in patients without ACS. |
| Korosoglou et al., 2011b | hsTnT | 256-slice CT | 124 | HsTnT is closely related to coronary plaque composition. |
| Blaha et al., 2011 | hsCRP | 4-slice CT for CAC | 6762 | hsCRP is not associated with coronary calcification. |
| Duivenvoorden et al., 2013 | Myeloperoxidase (MPO), hsCRP | 18FDG-PET/CT | 130 | MPO levels are associated with carotid plaque inflammation. |
| Andrassy et al., 2012 | HMBG-1 | 256-slice CT | 152 | HMBG1 is associated with the atherosclerotic plaque composition. |
| Nakazato et al., 2013 | LDL, HDL and total cholesterol | ≥64-slice CT | 4575 | Non-HDL is associated with non-calcified coronary plaque. |
| Voros et al., 2013 | ApoB, HDL, LDL | 64-sl. MDCT IVUS/VH | 60 | ApoB and small HDL particles are associated with larger plaque burden and non-calcified plaque. |
CAD, Coronary artery disease; LDL, low-density lipoprotein; HDL, high-density lipoprotein; ApoB, Apolipoprotein B; hsTnT, high-sensitive Troponin T; hsCRP, high-sensitive C-reactive protein; MPO, myeloperoxidase; CT, computer tomography; CAC, coronary artery calcification.