Table 1.

Gene expression profile of the different receptors of CAFs-secreted factors among WT and K303R ERα-expressing MCF-7 breast cancer cells.

Gene Name	Gene Symbol	Parametric P-value	Fold Change in K303R Clones
Leptin receptor	ObR/LepR	<1e-07	2.4
Interleukin 28 receptor α	IL28RA	<1e-07	1.9
Chemokine (C-X-C motif) receptor 4	CXCR4	<1e-07	1.9
Insulin receptor	IR	1.7e-06	1.68
Interleukin 17 receptor C	IL17RC	7e-07	1.6
Insulin-like growth factor 2 receptor	IGF2R	1e-07	1.57
Interleukin 15 receptor β	IL15RA	3e-07	1.5
Macrophage stimulating receptor 1	MSR1	9.2e-06	1.44
Hepatocyte growth factor receptor	MET	1.69e-05	1.39
Interleukin 1 receptor, type I	IL1R1	0.0004	1.38
Chemokine (C-C motif) receptor 7	CCR7	0.0001	1.3
Chemokine (C-X3-C motif)	CX3CR1	7.9e-05	1.32
receptor 1			1.27
Interleukin 2 receptor β	IL2RB	3.57e-05	1.25
Interleukin 9 receptor	IL9R	0.0002	1.23
Interleukin 10 receptor β	IL10RB	0.0003	1.21
Interleukin 6 receptor	IL6R	0.01	1.2
Interleukin 21 receptor	IL21R	0.0006	0.8
Interleukin 4 receptor	IL4R	0.0007	0.7
Epidermal growth factor receptor	EGFR	7.6e-06	0.7
Insulin-like growth factor 1 receptor	IGF1R	0.0006	0.7
Fibroblast growth factor receptor 3	FGFR3	0.0005	0.7

Representative probesets from pathway analysis showing gene expression changes in the receptor family of CAFs-secreted factors along with the p-value and the fold change of K303R-expressing cells compared to WT cells studied by microarray analysis. In cases where the same genes were deemed significant across multiple probesets, only one is shown.