Skip to main content
. Author manuscript; available in PMC: 2014 Aug 6.
Published in final edited form as: Bioorg Med Chem Lett. 2012 Nov 22;23(2):552–557. doi: 10.1016/j.bmcl.2012.11.022

Table 1.

Anti-proliferative activities NA-1 analogues.

graphic file with name nihms604364u1.jpg
R R′ SKBr3 (μM) MCF-7 (μM)
KU-398 graphic file with name nihms604364t1.jpg H 0.76±0.17a 1.09±0.10
12 graphic file with name nihms604364t2.jpg OAc 0.74±0.01 1.65±0.11
14 graphic file with name nihms604364t3.jpg OAc 0.88±0.09 1.88±0.45
15 graphic file with name nihms604364t4.jpg OAc 0.64±0.06 0.71±0.03
16 graphic file with name nihms604364t5.jpg OAc 0.62±0.04 0.82±0.07
17 graphic file with name nihms604364t6.jpg H 0.64±0.06 0.71±0.03
18 graphic file with name nihms604364t7.jpg H 1.30±0.63 2.64±0.45
19 graphic file with name nihms604364t8.jpg H 0.60±0.01 0.79±0.10
20 graphic file with name nihms604364t9.jpg H 0.92±0.56 1.55±0.04
29 graphic file with name nihms604364t10.jpg H 1.01±0.03 1.20±0.12
30 graphic file with name nihms604364t11.jpg H 0.82±0.02 0.93±0.21
31 graphic file with name nihms604364t12.jpg H >50 >50
32 graphic file with name nihms604364t13.jpg H >50 >50
33 graphic file with name nihms604364t14.jpg H 0.72±0.01 0.99±0.04
a

Values represent mean ± standard deviation for at least two separate experiments performed in triplicate