Skip to main content
. Author manuscript; available in PMC: 2014 Aug 6.
Published in final edited form as: Bioorg Med Chem Lett. 2012 Nov 22;23(2):552–557. doi: 10.1016/j.bmcl.2012.11.022

Table 3.

Anti-proliferative activity of NA-2 derivatives with cyclic N-substitutions

graphic file with name nihms604364u3.jpg
R1 R2 SKBr3 (μM) MCF-7 (μM)
37a Cyclohexyl H 0.66±0.12a 1.07±0.35
37b Cyclohexyl CH3 0.97±0.03 1.08±0.07
37c Phenyl H >50 >50
37d Phenyl CH3 >50 >50
37e Benzyl H 0.47±0.16 0.91±0.01
37f (R)-1-phenylethyl H 1.00±0.31 1.45±0.20
37g Cumenyl H 0.96±0.01 1.07±0.01
37h Benzyl CH3 10.73±0.49 11.52±4.16
37i graphic file with name nihms604364t15.jpg H 0.77±0.13 1.03±0.12
37j Adamantyl H 0.31±0.04 0.32±0.03
a

Values represent mean ± standard deviation for at least two separate experiments performed in triplicate