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. Author manuscript; available in PMC: 2014 Aug 16.
Published in final edited form as: J Org Chem. 2013 Aug 1;78(16):7859–7884. doi: 10.1021/jo401027r

Table 3.

Anti-proliferative activity produced by 3,5-dimethoxychroman-3-ol esters.

graphic file with name nihms604354u4.jpg
Entry R1 R2 R3 MCF-7 (IC50, μM) SKBr3 (IC50, μM)
27a H H H 14.02 ± 0.91 44.605 ± 5.40
27b OMe H H 0.77 ± .02 0.88 ± 0.06
27c H OMe H 32.89 ± 2.05 50.40 ± 1.39
27d m-OMePh OMe H 31.20 ± 18.17 80.13 ± 9.67
27e Prenyl OAc H 38.66 ± 7.71 47.90 ± 0.71
27f OMe OMe H 10.89 ± 0.27 36.98 ± 5.24
27g OMe H OMe 21.8 ± 3.08 29.5 ± 1.5
27h OEt H H 8.19 ± 0.16 33.35 ± 4.81
28a OH H H 37.72 ± 6.75 64.11 ± 13.95
28b H OH H 17.51 ± 0.86 17.73 ± 5.97
28c OH H OH >100 >100
28d OH OH H 22.12 ± 1.01 30.63 ± 11.89
28e OMe OH H 51.29 ± 1.13 76.50 ± 1.10