Table 4.
Anti-proliferative activity produced by analogues containing amide linkers.
| ||||
|---|---|---|---|---|
| Entry | R1 | R2 | MCF-7 (IC50, μM) | SKBr3 (IC50, μM) |
| 31a | H | H | >100 | >100 |
| 31b | OMe | H | >100 | >100 |
| 31c | m-OMePh | OMe | >100 | >100 |
| 31d | Prenyl | OAc | 54.5 ± 0.6 | 55.2 ± 1.2 |
Anti-proliferative activity produced by analogues containing amide linkers.
| ||||
|---|---|---|---|---|
| Entry | R1 | R2 | MCF-7 (IC50, μM) | SKBr3 (IC50, μM) |
| 31a | H | H | >100 | >100 |
| 31b | OMe | H | >100 | >100 |
| 31c | m-OMePh | OMe | >100 | >100 |
| 31d | Prenyl | OAc | 54.5 ± 0.6 | 55.2 ± 1.2 |