Table 4.
Pooled outcomes of subgroup analysis for studies with comparable tumor size or risk index
|
Outcomes |
Number of studies |
Sample size |
Heterogeneity (
P, I
2
) |
Overall effect size |
95% CI of overall effect |
P
|
|
|---|---|---|---|---|---|---|---|
| LAP | OPEN | ||||||
| Operation time (min) |
13 |
371 |
377 |
<0.001, 81% |
WMD = -1.06 |
-16.93, 14.81 |
0.90 |
| Blood loss (ml) |
11 |
300 |
302 |
<0.001, 71% |
WMD = -58.20 |
-81.76, -34.65 |
<0.01 |
| Time to first flatus (d) |
6 |
129 |
142 |
0.09, 47% |
WMD = -1.28 |
-1.60, -0.97 |
<0.01 |
| Time to oral intake (d) |
7 |
212 |
241 |
0.02, 61% |
WMD = -1.77 |
-2.18, -1.35 |
<0.01 |
| Hospital stay (d) |
11 |
309 |
339 |
0.006, 60% |
WMD = -2.87 |
-3.54, -2.21 |
<0.01 |
| Overall complications |
12 |
341 |
345 |
0.74, 0% |
RR = 0.49 |
0.30, 0.81 |
<0.01 |
| Tumor size (cm) |
13 |
371 |
377 |
0.23, 21% |
WMD = -0.57 |
-0.86, -0.29 |
<0.01 |
| Recurrence | 8 | 248 | 232 | 0.81, 0% | RR = 0.66 | 0.31, 1.42 | 0.29 |
CI, confidence interval; LAP, laparoscopic surgery; OPEN, open surgery; RR, risk ratio; WMD, weighted mean difference.