. Author manuscript; available in PMC: 2015 Jun 1.

Published in final edited form as: Circ Cardiovasc Genet. 2014 May 13;7(3):321–331. doi: 10.1161/CIRCGENETICS.113.000208

Table 3.

Estimated effects of top SNPs in main analysis and secondary analysis adjusting for preceding fatty acid in metabolic pathway.

Fatty acid (outcome)	Preceding fatty acid (covariate)	Correlation^*	Most significant SNP	Risk allele	Estimated effect (p-value) Main analysis	Estimated effect (p-value) Secondary analysis
GLA (18:3,n6)	LA (18:2,n6)	−.26	rs174547	c	−.016 (2.3x10⁻⁷²)	−.0085 (1.5x10⁻²⁰)
GLA (18:3,n6)	LA (18:2,n6)	−.26	rs16966952	a	−.0061 (5.0x10⁻¹¹)	−.0042 (3.1x10⁻⁶)
DGLA (20:3,n6)	GLA (18:3,n6)	.22	rs174547	c	.36 (2.6x10⁻¹⁵¹)	.42 (1.7x10⁻¹⁸⁴)
DGLA (20:3,n6)	GLA (18:3,n6)	.22	rs16966952	a	−.22 (7.6x10⁻⁶⁵)	−.20 (1.8x10⁻⁵⁶)
AA (20:4,n6)	DGLA (20:3,n6)	−.15	rs174547	c	−1.69 (3.0x10⁻⁹⁷¹⁾	−1.79 (5.0x10⁻⁸⁵⁰)
AA (20:4,n6)	DGLA (20:3,n6)	−.15	rs16966952	a	−.20 (2.4x10⁻¹⁰)	−.29 (1.3x10⁻¹⁷)
AdrA (22:4,n6)	AA (20:4,n6)	.49	rs174547	c	−.048 (6.3x10⁻¹⁴⁰)	.0056 (2.0x10⁻²)
AdrA (22:4,n6)	AA (20:4,n6)	.49	rs3134950	c	−.0097 (5.7x10⁻⁶)	−.012 (2.1x10⁻¹⁰)

Pearson correlation coefficient between the two fatty acids