Figure 1. An in-slico tumor consisting of a proliferative (phenotype 1) and a hypoxia-induced invasive (phenotype 2) sub-population as grows under poorly-vascularized (on the left column) and well-vascularized conditions (on the right column).

A, D) The evolution of the corresponding normoxic sub-populations of each phenotype illustrates the dominance of phenotype 2. B, E) A central cross section of the tumor at day 50 and day 200 showing the spatial distribution of the viable sub-populations of the two phenotypes, respectively. C, F) The spatial distribution of viable (normoxic and hypoxic) cells after 200 fictitious days varying from blue color at the lowest cell density to red color at the highest observed as depicted in the corresponding colorbar.