Table 2. Clinical differences between clusters, and list of defined peptides that resulted differentially expressed between the subgroups.

	Accession Number	Cluster 1 (no.22)	Cluster 2 (no.10)	Cluster 3 (no.19)
MS course (CIS/RR/Pr)	–	9/5/8	3/6/1	12/5/2
Age at disease onset (years)	–	36.32 (11.93)	23.191 (9.26)	29.81 (9.78)
Complement 3F (1305–1319)	P01024	0.18 (0.22)	0.04 (0.04)	0.05 (0.13)
Secretogranin II (529–566)	P13521	2.29 (1.05)	3.97 (1.68)	2.31 (0.77)
Protein 7B2 (182–212)	P05408	4.63 (1.37)	8.87 (2.82)	6.74 (1.37)
Chromogranin A (97–131)	P10645	2.99 (1.35)	0.74 (1.11)	3.43 (0.73)
Chromogranin B (273–303)	P05060	0.22 (0.23)	0.031 (0.08)	0.73 (0.37)
Thymosin β4	P62328	0.23 (0.24)	0.021 (0.05)	0.36 (0.29)
Osteopontin (249–314)*	P10451	0.07 (0.10)	0.003 (0.02)	0.23 (0.11)
Fibrinogen (560–600)	P02671	0.17 (0.29)	0.11 (0.15)	0.13 (0.45)
Fibrinopeptide A (21–35)	P02671	0.37 (0.42)	0.55 (0.75)	0.95 (2.45)

Footnote: *Peptide phosphorylated.