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. 2014 Aug 6;9(8):e104216. doi: 10.1371/journal.pone.0104216

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© 2014 Okinami et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Isometric tension measurement of bladder smooth muscle strips from the CYP-induced cystitis group (CYP; n = 6) and the sham-treated control group (CTRL; n = 5) were performed with or without Bay K8644 (Bay K) or carbenoxolone (CBX). A: Representative data revealed that spontaneous contraction and its enhancement by Bay K8644 were observed in the CYP group. Bay K8644-induced spontaneous contraction was blocked by CBX in the CYP group. B–D: Evaluation of parameters of spontaneous contraction. Frequency per 10 minutes (B), peak amplitude (C) and area under the curve (D) of spontaneous contraction increased in the CYP group when compared to the control group. CBX down-regulated increased levels of each parameter of spontaneous contraction in the CYP group (B–D).