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. 2014 Aug 6;9(8):e104216. doi: 10.1371/journal.pone.0104216

Figure 5. Voiding behavior in mice with cystitis treated with 18α-glycyrrhetinic acid (GA).

Figure 5

Micturition patterns were analyzed in the CYP-induced cystitis group in the presence (CYP+GA; n = 5) or absence (as control, CYP; n = 6) of 18α-GA with the aVSOP method. A: Maximum voided volume per void. The CYP+GA group demonstrated a significantly increased volume at 48 and 60 hours when compared to the control group. B: Mean voided volume per void. The CYP+GA group revealed a significant increase in volume at 48 hours. C: Urinary frequency per 12 hours. The CYP+GA group revealed lower frequency at each period examined. D: Total urine volume per 12 hour. The CYP+GA group revealed greater volume at each period. The white and black triangles show the time of 18α-GA and CYP administration, respectively. On the X-axis, the black squares indicate dark periods (9∶00 pm to 9∶00 am) and the white squares indicate light periods (9∶00 am to 9∶00 pm). Two way repeated measure ANOVA and Bonferroni post-test were performed. P<0.05 was regarded as statistically significant; *P<0.05, ***P<0.001.