Table 1. Intraclass Correlation Coefficient of HOME Study Children’s Urinary Phthalate Metabolite Concentrations Collected (A) Annually from 1–5 Years of Age and (B) Twice ∼2 Weeks Apart at 1–3 Years of Agea.
A: annual ICCs | B: short-term
ICCs |
||||
---|---|---|---|---|---|
metabolite | allb | 1 year | 2 years | 3 yrs | allb |
unadjusted | N = 283 subjects; 1,070 samplesc | N = 16 subjects | N = 25 subjects | N = 27 subjects | N = 61 subjects; 136 samplesd |
∑DEHPe | 0.18 (0.10, 0.27) | 0.35 (0.00, 0.61) | 0.27 (0.00, 0.67) | 0.44 (0.00, 0.73) | 0.29 (0.05, 0.49) |
MBzP | 0.26 (0.17, 0.35) | 0.51 (0.30, 0.63) | 0.14 (0.00, 0.42) | 0.56 (0.29, 0.74) | 0.34 (0.09, 0.54) |
MCPP | 0.20 (0.12, 0.29) | 0.57 (0.18, 0.85) | 0.29 (0.00, 0.67) | 0.45 (0.00, 0.75) | 0.31 (0.09, 0.49) |
MCOP | 0.17 (0.09, 0.26) | 0.54 (0.13, 0.85) | 0.00 (0.00, 0.37) | 0.16 (0.00, 0.50) | 0.15 (0.00, 0.33) |
MCNP | 0.21 (0.13, 0.29) | 0.71 (0.37, 0.86) | 0.20 (0.00, 0.59) | 0.25 (0.00, 0.70) | 0.25 (0.09, 0.41) |
MEP | 0.36 (0.26, 0.45) | 0.30 (0.08, 0.52) | 0.39 (0.15, 0.61) | 0.53 (0.13, 0.79) | 0.32 (0.08, 0.53) |
MnBPf | 0.22 (0.02, 0.43) | N/Af | N/Af | N/Af | N/Af |
MiBPf | 0.30 (0.10, 0.49) | N/Af | N/Af | N/Af | N/Af |
Creatinine Adjusted | |||||
∑DEHPe | 0.11 (0.03, 0.19) | 0.41 (0.00, 0.85) | 0.24 (0.00, 0.56) | 0.52 (0.16, 0.81) | 0.20 (0.00, 0.41) |
MBzP | 0.25 (0.18, 0.35) | 0.26 (0.08, 0.42) | 0.25 (0.03, 0.56) | 0.61 (0.35, 0.75) | 0.39 (0.19, 0.57) |
MCPP | 0.19 (0.11, 0.27) | 0.60 (0.19, 0.91) | 0.60 (0.21, 0.83) | 0.34 (0.00, 0.63) | 0.25 (0.07, 0.43) |
MCOP | 0.15 (0.06, 0.24) | 0.50 (0.00, 0.86) | 0.00 (0.00, 0.26) | 0.22 (0.00, 0.59) | 0.03 (0.00, 0.20) |
MCNP | 0.19 (0.09, 0.27) | 0.72 (0.45, 0.91) | 0.28 (0.00, 0.69) | 0.17 (0.00, 0.79 | 0.19 (0.00, 0.38) |
MEP | 0.35 (0.22, 0.44) | 0.46 (0.29, 0.61) | 0.28 (0.00, 0.72) | 0.66 (0.38, 0.85) | 0.29 (0.00, 0.52) |
MnBPf | 0.20 (0.01, 0.39) | N/Af | N/Af | N/Af | N/Af |
MiBPf | 0.31 (0.06, 0.50) | N/Af | N/Af | N/Af | N/Af |
Creatinine z-Score Adjusted | |||||
∑DEHPe | 0.09 (0.02, 0.16) | 0.46 (0.07, 0.75) | 0.28 (0.00, 0.53) | 0.48 (0.26, 0.67) | 0.20 (0.00, 0.40) |
MBzP | 0.25 (0.16, 0.34) | 0.39 (0.22, 0.53) | 0.42 (0.20, 0.68) | 0.59 (0.35, 0.79) | 0.36 (0.16, 0.55) |
MCPP | 0.19 (0.11, 0.26) | 0.64 (0.43, 0.86) | 0.59 (0.32, 0.78) | 0.33 (0.07, 0.53) | 0.25 (0.08, 0.43) |
MCOP | 0.13 (0.03, 0.22) | 0.47 (0.22, 0.63) | 0.00 (0.00, 0.11) | 0.22 (0.00, 0.40) | 0.03 (0.00, 0.20) |
MCNP | 0.20 (0.09, 0.28) | 0.61 (0.51, 0.68) | 0.24 (0.00, 0.53) | 0.18 (0.00, 0.66) | 0.19 (0.00, 0.38) |
MEP | 0.39 (0.26, 0.48) | 0.50 (0.36, 0.67) | 0.33 (0.02, 0.69) | 0.76 (0.30, 0.88) | 0.33 (0.04, 0.56) |
MnBPf | 0.16 (0.00, 0.38) | N/Af | N/Af | N/Af | N/Af |
MiBPf | 0.31 (0.07, 0.50) | N/Af | N/Af | N/Af | N/Af |
creatinine | 0.18 (0.08, 0.28) | 0.45 (0.21, 0.65) | 0.03 (0.00, 0.40) | 0.30 (0.00, 0.54) | 0.17 (0.00, 0.34) |
ICC = intraclass correlation coefficient; N/A = not available.
Models adjusted for visit number.
All participants with at least 2 phthalate measurements, but not necessarily complete covariate information.
Some participants provided 2 urine samples in multiple years but are counted only once in the final column.
∑DEHP= Sum of MEHP, MEHHP, MEOHP, and MECPP.
MnBP and MiBP measured only at 4 and 5 years of age.