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. 2014 Aug 6;9(8):e104105. doi: 10.1371/journal.pone.0104105

Table 1. Total costs of TB diagnostic tests and market value in the public sector in Brazil, 2012, in USD.

Diagnostic test Cost pertest No. of testsdone inpublic sector % of totalvolume,public sector Total value,public sector % of total value,public sector
TST 5.90 725,000 33.6% 4,278,555 28.3%
IGRA Not done Not done
Sputum smearmicroscopy (ZN) 2.85 1,139,367 52.8% 3,245,596 21.5%
Culture (liquid) 31.43 91,445 4.2% 2,874,409 19.0%
Culture (solid) 16.36 168,432 7.8% 2,756,024 18.2%
Xpert MTB/RIF 17.80 18,000 0.8% 320,400 2.1%
LPA Not done Not done
PCR 44.99 614 <0.1% USD 27,624 0.2%
First line DST(liquid, SIRE) 130.54 9,049 0.4% USD 1,181,212 7.8%
First line DST(liquid, SIREP) 196.65 539 <0.1% USD 105,995 0.7%
First line DST(solid, SIRE) 41.11 5,519 0.3% 226,861 1.5%
Second line DST(liquid, 4 drugs) 130.54 699 <0.1% 91,244 0.6%
Total 2,158,664 100% 15,107,921 100%

TST = tuberculin skin test; IGRA = Interferon gamma release assay; ZN = Ziehl-Neelsen; LPA = line probe assay; PCR = polymerase chain reaction; DST = drug susceptibility test; SIRE = Streptomycin, Isoniazid, Rifampin, Ethambutol; SIREP = Streptomycin, Isoniazid, Rifampin, Ethambutol, Pyrazinamide; USD = United States Dollars.