Table 2. Physicochemical characterization of PTX-loaded PEG-FTS micelles.
| carrier/PTX ratio | PTX loaded micellesa | sizeb (nm) | PDIc | DLCd (%) | DLEe (%) | stabilityf (hours) |
|---|---|---|---|---|---|---|
| 1:1 | PEG2K-FTS2/PTX | precipitate | ||||
| PEG2K-FTS4/PTX | precipitate | |||||
| PEG5K-FTS2/PTX | precipitate | |||||
| PEG5K-FTS4/PTX | 54.40 | 0.13 | 6.6 | 60.2 | 2.5 | |
| 2.5:1 | PEG2K-FTS2/PTX | 29.27 | 0.09 | 8.2 | 76.8 | 1.5 |
| PEG2K-FTS4/PTX | 42.55 | 0.24 | 6.4 | 80.2 | 3 | |
| PEG5K-FTS2/PTX | 24.90 | 0.35 | 4.5 | 81.2 | 2 | |
| PEG5K-FTS4/PTX | 28.16 | 0.17 | 4.0 | 85.6 | 20 | |
| 5:1 | PEG2K-FTS2/PTX | 28.68 | 0.09 | 5.0 | 89.2 | 5 |
| PEG2K-FTS4/PTX | 25.60 | 0.11 | 3.8 | 90.6 | 28 | |
| PEG5K-FTS2/PTX | 25.63 | 0.23 | 2.8 | 97.6 | 20 | |
| PEG5K-FTS4/PTX | 26.52 | 0.08 | 2.3 | 94.2 | 48 |
a
PTX concentration in micelles was kept at 1 mg/mL.
b
Measured by dynamic light scattering particle sizer.
c
PDI = polydispersity index.
d
DLC = drug loading capacity.
e
DLE = drug loading efficiency.
f
Data mean that there was no noticeable size change during the follow-up period.