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Proximal phospho(ribosyl)ation sites. E488 and E491 are previously characterized PARP-1 automodification sites, shown here in panels b and c, respectively, as compared with the unmodified form of the peptide shown in panel a. The doubly modified peptide (d) contains diagnostic fragments that carry one phosphoribose group (212.01 Da, circles) as well as those carrying two phosphoribose groups (424.02 Da, squares).
