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. 2014 May 5;11(8):2553–2565. doi: 10.1021/mp500161z

Figure 1.

Figure 1

(A) Schematic of drug efflux by Pgp export. As a lipophilic drug enters the membrane, it encounters the intramembrane access point of Pgp. (B) Aller’s model of substrate transport by Pgp.15 The drug first enters the membrane, where it encounters and then enters Pgp (B,A), and then the conformational change of Pgp expels the drug out of the cell (B,B).15 (C) Crystal structure of Pgp. Panels B and C are reprinted with permission from ref (15). Copyright 2009 American Association for the Advancement of Science.