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. 2014 Aug 6;9(8):e104653. doi: 10.1371/journal.pone.0104653

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© 2014 Kotzerke et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Representative images of agarose gels in the absence (A) or presence (B) of DMSO. The plasmid DNA samples were irradiated for 24 h with 50–1250 MBq/mL ^99mTc-HYNIC-DAPI. The influence of DMSO on DNA damage (OC: open circular, L: linear, SC: super coiled plasmid DNA fraction) caused by ^99mTc-HYNIC-DAPI was compared with that elicited by ^99mTc-pertechnetate (^99mTcO₄ ⁻). Notably, the formation of open circular and linear DNA in response to ^99mTc-pertechnetate could be prevented by DMSO. The first lane is a non-irradiated plasmid sample, L is a non-irradiated linear plasmid, and M is the marker. The DNA bands at the bottom represent supercoiled DNA.