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View full-text article in PMC

. 2014 Aug 6;9(8):e104653. doi: 10.1371/journal.pone.0104653

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© 2014 Kotzerke et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The influence of the radical scavenger DMSO on the DNA conformational changes caused by ^99mTc-pertechnetate and ^99mTc-HYNIC-DAPI after 2 (A) or 24 h (B) of irradiation. The formation of open circle and linear DNA in response to ^99mTc-pertechnetate was nearly completely suppressed in the presence of DMSO. These data indicated that the plasmid damage by ^99mTc-pertechnetate was primarily caused by radicals. There was no noticeable effect of DMSO in the ^99mTc-HYNIC-DAPI-treated samples, indicating that the plasmid damage was caused by direct interactions between the radioactive compound and the DNA.