Table 1.
Changes of SBP during the study
| Group | SBP (mmHg) | ||
|---|---|---|---|
| Base line | At 4 weeks | At 8 weeks | |
| WKY | 126.00 ± 6.395 | 126.80 ± 6.224 | 119.40 ± 5.600 |
| SHR | 206.60 ± 5.316* | 201.40 ± 3.881* | 207.40 ± 2.159* |
| SHR+LA | 203.80 ± 3.878* | 175.00 ± 3.847#,* | 165.40 ± 3.544#,* |
| SHR+HA | 201.60 ± 6.185* | 166.20 ± 3.023#,* | 163.60 ± 2.482#,* |
Values, mean ± SEM; n = 5–6; *P < 0.01 versus WKY controls; #P < 0.01 versus SHR controls. SBP: systolic blood pressure; WKY: Wistar; SHR: spontaneously hypertensive rats; LA: low dose of Aliskiren; HA: high dose of Aliskiren.