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. 2014 Apr 13;18(7):1300–1312. doi: 10.1111/jcmm.12281

Fig. 4.

Fig. 4

Neural stem cells (NSCs) affected the expression of effector molecules by microglia. The expression of effector molecules was analysed by real-time polymerase chain reaction as described in the Materials and methods section. (A and B) NSCs affected TNF-α and IL-10 mRNA expression in the brain slices. (C–E) NSCs increased CX3CR1, IGF-1 and TREM2 mRNA expression in the brain slices. Results are shown as means ± SD (n = 5). (F and G) NSCs affected TNF-α and IL-10 mRNA expression in primary microglia cells. (H–J) NSCs increased CX3CR1, IGF-1 and TREM2 mRNA expression in primary microglia cells. Results are shown as means ± SD of at least three independent experiments. Abbreviations: TREM2: triggering receptor expressed on myeloid cells 2; CX3CR1: CX3C chemokine receptor; IGF-1: insulin growth factor 1; TNF-α: tumour necrosis factor α.