Table 3.
The association between the BUD13/ZNF259 polymorphisms with hypercholesterolaemia
| Hypercholesterolaemia | ||||||
|---|---|---|---|---|---|---|
| SNP | Genotype | Genotype distribution, n (%) | OR (95%CI) | P-value | ||
| Cases (n = 557) | Controls (n = 547) | P-value | ||||
| ZNF259 1093-336G>A rs2075290 | AA | 268 (48.1) | 296 (54.1) | 1.22 (0.74, 2.02) | 0.437 | |
| AG/GG | 289 (59.8) | 251 (45.9) | 0.135 | |||
| MAF | 333 (29.9) | 288 (26.3) | 0.062 | |||
| ZNF259 *365 + 359C>G rs964184 | CC | 309 (55.5) | 335 (61.2) | 0.69 (0.33, 1.47) | 0.340 | |
| CG/GG | 248 (34.5) | 212 (38.8) | 0.097 | |||
| MAF | 286 (25.7) | 238 (21.8) | 0.030 | |||
| BUD13 237 + 1741T>C rs10790162 | GG | 340 (62.2) | 307 (56.1) | 2.23 (1.05, 4.75) | 0.015 | |
| GA/AA | 217 (37.8) | 240 (44.0) | 0.025 | |||
| MAF | 234 (21.4) | 294 (26.4) | 0.006 | |||
| BUD13 323-575A>G rs17119975 | AA | 381 (68.4) | 339 (62.0) | 0.95 (0.69, 1.31) | 0.743 | |
| AG/GG | 176 (28.4) | 208(38.0) | 0.078 | |||
| MAF | 194 (17.4) | 231 (21.1) | 0.027 | |||
| BUD13 *147C>T rs11556024 | CC | 480 (86.2) | 458 (83.7) | 0.92 (0.61, 1.39) | 0.683 | |
| CT/TT | 77 (13.8) | 89 (16.3) | 0.472 | |||
| MAF | 78 (7.0) | 91 (8.0) | 0.245 | |||
| BUD13 64G>T rs35585096 | CC | 548 (98.4) | 541 (98.9) | 0.76 (0.21, 2.75) | 0.676 | |
| CA | 9 (1.6) | 6 (1.1) | 0.457 | |||
| MAF | 9 (0.8) | 6 (0.6) | 0.451 | |||
MAF, minor allele frequency; ZNF259, zinc finger protein 259; BUD, BUD13 homolog.