Table 1.

Urine output in preterm infants with patent ductus arteriosus following the administration of ibuprofen or indomethacin

Ibuprofen			Indomethacin			P-value	Reference
Urine output	Doses: Initial, after 24 h, after 48 h (mg/kg)	Number of infants	Urine output	Daily dose, for 3 days (mg/kg)	Number of infants
1.79±0.61a	10, 5, 5	52	1.44±0.74a	A	88	0.002	21
4.0±1.4b	10, 5, 5	185	3.6±1.4b	B	165	0.008	15
3.5±1.2b	10, 5, 5	94	2.8±1.2b	0.2	81	<0.05	20
3.6±1.3b	10, 5, 5	32	2.8±1.1b	0.2	31	<0.02	25

Notes: Urine output is the mean ± standard deviation.

^ag/kg/h;

^bmL/kg/h. A: Indomethacin was given in three doses at 24-hour intervals depending on patient age (<48 hours of life, the initial dose was 0.2 mg/kg, followed by 0.1 mg/kg × two doses every 24 hours. When the age was 2–7 days, the dose of indomethacin was 0.2 mg/kg three times a day. When the age was >7 days, the initial indomethacin dose was 0.2 mg/kg, followed by two doses of 0.25 mg/kg every 24 hours). B: When the body weight was <750 g, the initial indomethacin dose was 0.2 mg/kg, followed by two doses of 0.1 mg/kg every 24 hours. When the body weight was from 750 to 1,000 g, the indomethacin dose was 0.2 mg/kg daily for 3 days. When the body weight was >1,000 g, the dose of indomethacin was 0.2 mg/kg every 12 hours.

Abbreviation: h, hous.