Table 2.

Serum creatinine concentrations in preterm infants treated with ibuprofen or indomethacin for the closure of the patent ductus arteriosus

Time after dosing	Ibuprofen			Indomethacin			P-value	Reference
	Creatinine concentration (mg/dL)	Doses: Initial, after 24 h, after 48 h (mg/kg)	Number of infants	Creatinine concentration (mg/dL)	Daily dose, for 3 days (mg/kg)	Number of infants
NA	0.98±0.24	10, 5, 5	185	1.06±0.24	A	165	0.005	15
24 hours	1.05±0.36	10, 5, 5	73	1.33±0.46	0.2	46	<0.001	22
2–7 days	1.11±0.39			1.53±0.5			<0.001
24 hours	1.30±0.35	10, 5, 5	32	1.71±0.62	0.2	31	<0.01	24
48 hours	1.48±0.27			2.03±2.10			<0.01
NA	81±20.0a	10, 5, 5	94	89±24.0a	0.2	81	<0.05	20

Notes: Creatinine concentrations are the mean ± standard deviation.

^aμmol/L. A: When the body weight was <750 g, the initial indomethacin dose was 0.2 mg/kg, followed by two daily doses of 0.1 mg/kg. When the body weight was 750–1,000 g, the indomethacin dose was 0.2 mg/kg for 3 days. When the body weight was >1,000 g, the indomethacin dose was 0.2 mg/kg every 12 hours.

Abbreviation: NA, not available.