Table 3.

Number of preterm infants with oliguria following the administration of ibuprofen or indomethacin for the closure of the patent ductus arteriosus

Ibuprofen			Indomethacin			P-value	Reference
Number of infants treated with ibuprofen	Number of infants with oliguria	Percentage of infants with oliguria	Number of infants treated with indomethacin	Number of infants with oliguria	Percentage of infants with oliguria
94	1	1.0	81	12	14.8	0.017	20
74	5	6.7	74	14	18.9	0.037	10
22	1	5.0	20	8	40.0	0.02	25a
52	5	9.6	88	33	37.5	0.002	21

Notes:

^aInfants with a body weight <1,000 g. Indomethacin was given in three doses at 24-hour intervals depending on patient age (<48 hours of life, the initial dose was 0.2 mg/kg, followed by 0.1 mg/kg × two doses every 24 hours. When the age was 2–7 days, the dose of indomethacin was 0.2 mg/kg × three times daily. When the age was >7 days, the initial indomethacin dose was 0.2 mg/kg, followed by two doses of 0.25 mg/kg every 24 hours). Ibuprofen was administered at the dose of 10 mg/kg, followed by 5 mg/kg after 24 and 48 hours.