Table 2.
Clinical data for performance of artificial tears and their corresponding percent improvement based upon respective subjective and objective criteria
| Brand name | Pts treated (n) | Trials (n) | Improvement (%) |
|---|---|---|---|
| Thera Tears®,80 | 2 | 1 | 100 |
| Refresh Tears®,68,37,41,54,47,70,30 | 739 | 7 | 100 |
| Refresh Plus®,69,71,72,32,82,35 | 301 | 6 | 92.7 |
| Refresh Celluvisc®,80 | 11 | 1 | 100 |
| Refresh Liquigel®,41,29,30,74 | 778 | 4 | 100 |
| GenTeal® Moderate to Severe50 | 37 | 1 | 100 |
| Lacril®,81 | 55 | 1 | 100 |
| Isopto® Alkaline80 | 2 | 1 | 100 |
| Isopto® Plain80 | 9 | 1 | 100 |
| Blink® Tears45 | 20 | 1 | 100 |
| Blink® Intensive Tears75,44,90 | 60 | 3 | 100 |
| Systane® Balance83,84,33 | 92 | 3 | 71.0 |
| Systane®,68,37,28,85,57,34,44,86,88,89 | 502 | 10 | 87.3 |
| Systane® Ultra54,79,36,40 | 130 | 4 | 100 |
| Systane®, preservative-free87 | 27 | 1 | 100 |
| Soothe®,47 | 30 | 1 | 100 |
| GenTeal® Gel55,56 | 206 | 2 | 96.0 |
| Viscotears®,73,80 | 456 | 2 | 100 |
| Liposic®,49 | 74 | 1 | 100 |
| Refresh Lacrilube®,80 | 239 | 1 | 100 |
| Tears Again® (Actimist in the UK)77,78,49 | 287 | 3 | 93.0 |
| Refresh Optive®,42,36,40,31 | 5,430 | 4 | 75.8 |
| Refresh Optive® Sensitive82 | 114 | 1 | 100 |
| Tears Naturale® II80 | 68 | 1 | 100 |
| Tears Naturale Free®,68 | 22 | 1 | 100 |
| Tears Naturale® Forte71,76 | 129 | 2 | 63.0 |
Notes: Improvement in DTS was defined in each study with the following subjective/objective criteria: subjective data: McMonnies Dry Eye Symptom survey, ODSI questionnaire, IDEEL questionnaire, SEE questionnaire, Ocular Discomfort Severity questionnaire, Direct Brand Comparison with drop preference selection, quality of life through the Measure Yourself Medical Outcome Profile-2 (MYMOP-2), Dry Eye Disease Comfort Assessment Score, and various custom questionnaires in addition to these. Objective data: McMonnies Dry Eye Symptom survey, ODSI questionnaire, IDEEL questionnaire, SEE Questionnaire, Ocular Discomfort Severity questionnaire, Direct Brand Comparison with drop preference selection, quality of life through the MYMOP-2, Dry Eye Disease Comfort Assessment Score, and various custom questionnaires in addition to these.23–31 Manufacturers are as follows: Thera Tears®, Advanced Vision Research, Ann Arbor, MI, USA; Refresh®, Allergan, Irvine, CA, USA; GenTeal®, Novartis Pharmaceuticals, East Hanover, NJ, USA; Lacril®, Allergan; Isopto®, Alcon Laboratories, Inc., Fort Worth, TX, USA; Blink®, Abbott Laboratories Inc., Abbott Park, IL, USA; Systane®, Alcon Laboratories, Inc.; Soothe®, Bausch & Lomb Incorporated, Bridgewater, NJ, USA; Viscotears®, Novartis Pharmaceuticals; Liposic®, Bausch & Lomb Incorporated; Tears Again®, OcuSoft, Rosenberg, TX, USA; Tears Naturale®, Alcon Laboratories, Inc.
Abbreviations: DTS, dysfunctional tear syndrome; IDEEL, impact of dry eye on everyday life; ODSI, Ocular Surface Disease Index; pts, patients.