Table S1.
Methylcellulose-based artificial tears commercially available
| Name | Active ingredients | Preservatives |
|---|---|---|
| GenTeal® Mild | 0.2% HPMC | GenAqua® (sodium perborate) |
| GenTeal® Moderate to Severe | 0.3% HPMC 0.25% CMC |
GenAqua® (sodium perborate) |
| Ultra Tears® | 0.3% HPMC | BAK |
| Tearisol® | 0.3% HPMC | BAK |
| Lacril® | 0.5% HPMC | Chlorobutonal |
| Isopto® Alkaline | 1.0% HPMC | BAK |
| Isopto® Plain | 0.5% HPMC | BAK |
| Isopto® Tears | 0.5% HPMC | BAK |
| Nature’s Tears® | 0.4% HPMC | BAK |
| Natural Balance Tears | 0.4% HPMC | BAK |
| Rohto® Hydra | 0.3% HPMC | Polyaminopropyl biguanide |
| Thera Tears® | 0.25% CMC | Preserved-forma Dequest (sodium perborate and phosphoric acid) |
| Refresh Tears® | 0.5% CMC | Purite (stabilized oxychloro complex) |
| Refresh Plus® | 0.5% CMC | None |
| Refresh Celluvisc® | 1.0% CMC | Preserved-forma Purite (stabilized oxychloro complex) |
| Refresh Liquigel® | 1.0% CMC | Preserved-forma Purite (stabilized oxychloro complex) |
| Just Tears | 0.5% CMC | Purite (stabilized oxychloro complex) |
Notes:
Both preserved and preservative-free formulations commercially available. Manufacturers are as follows: GenTeal®, Novartis Pharmaceuticals, East Hanover, NJ, USA; Ultra Tears®, Alcon Laboratories, Inc., Fort Worth, TX, USA; Tearisol®, Novartis Pharmaceuticals; Lacril®, Allergan, Irvine, CA, USA; Isopto®, Alcon Laboratories, Inc.; Nature’s Tears®, Bio-Logic Aqua Technologies, Grants Pass, OR, USA; Natural Balance Tears, Major Pharmaceuticals, Livonia, MI, USA; Rohto® Hydra, Rohto Laboratories Indonesia, Padalarang, Indonesia; Thera Tears®, Advanced Vision Research, Ann Arbor, MI, USA; Refresh®, Allergan; GenAqua®, Novartis Ophthalmics, East Hanover, NJ, USA; Just Tears, Blairex, Columbus, IN, USA.
Abbreviations: BAK, benzalkonium chloride; CMC, carboxy methylcellulose; HPMC, hydroxypropyl methylcellulose.