Table S4.
Gels, ointments, sprays, and an ophthalmic insert for dysfunctional tear syndrome
| Name | Active ingredients | Delivery | Preservatives |
|---|---|---|---|
| GenTeal® Gel | 0.3% HPMC | Gel | Preserved-forma |
| Carbopol 980 | GenAqua® | ||
| Tears Again® Night & Day Gel | 1.5% CMC | Gel | Dissipate (stabilized oxyborate complex) |
| Hylo®-Gel | 0.2% hyaluronic acid | Gel | None |
| ViscoTears® Liquid Gel | 0.2% carbomer 980 | Gel | None |
| Liquivisc™ | 0.25% carbomer 974P | Gel | BAK |
| Liposic® | 0.2% carbomer 980 | Gel | None |
| Soothe® Lubricant Eye Ointment | 20% mineral oil 80% white petrolatum |
Ointment | None |
| Akwa® Tears Ointment | 15% mineral oil 83% white petrolatum |
Ointment | None |
| Rugby® Artifical Tear Ointment | 15% mineral oil 83% white petrolatum |
Ointment | None |
| Puralube® Ointment | 15% mineral oil 85% white petrolatum |
Ointment | None |
| Lubrifresh™ PM | 15% mineral oil 83% white petrolatum |
Ointment | None |
| Refresh PM® Ointment | 42.5% mineral oil 57.3% white petrolatum |
Ointment | None |
| Tears Naturale® PM | 56.8% white petrolatum 42.5% mineral oil |
Ointment | None |
| Refresh Lacrilube® | 42.5% mineral oil 56.8% white petrolatum |
Ointment | Chlorobutanol |
| Systane® Nighttime Ointment | 3% mineral oil 94% white petrolatum |
Ointment | None |
| Clarymist™ | 1.0% woy lecithin | Spray | Phenoxyethanol |
| Actimist™ | 1% woy Lecithin | Spray | Phenoxyethanol |
| Name | Active ingredients | Delivery | Preservatives |
| Tears Again® | 1.4% PVA | Spray | Dissipate (stabilized oxyborate complex) |
| Nature’s Tears® | Bio-Logic Aqua® tissue-culture grade water | Spray | None |
| Vizulize Dry Eyes Eye Mist | 0.10% hyaluronate | Spray | N-IG |
| Lacrisert®,b | 5 mg HPMC | Insert | None |
Notes:
Both preserved and preservative-free formulations commercially available
Prescription-only ophthalmic insert. Manufacturers are as follows: GenTeal®, Novartis Pharmaceuticals, East Hanover, NJ, USA; Tears Again®, OcuSoft, Rosenberg, TX, USA; Hylo®-Gel, URSAPHARM, Saarbrücken, Germany; Viscotears®, Novartis Pharmaceuticals; Liquivisc™, URSAPHARM; Liposic®, Bausch & Lomb Incorporated, Bridgewater, NJ, USA; Soothe®, Bausch & Lomb Incorporated; Akwa®, Akorn, Incorporated, Lake Forest, IL, USA; Rugby®, Rugby Laboratories, Livonia, MI, USA; Puralube®, Fougera Pharmaceuticals Inc., Melville, NY, USA; Lubrifresh™, Major Pharmaceuticals, Livonia, MI, USA; Refresh®, Allergan, Irvine, CA, USA; Systane®, Alcon Laboratories, Inc., Fort Worth, TX, USA; Clarymist™, Savant Distribution, Leeds, UK; Actimist™, Reckitt Benckiser plc, Berkshire, UK; Nature’s Tears®, Bio-Logic Aqua Technologies, Grants Pass, OR, USA; Lacrisert®, Valeant Pharmaceuticals North America LLC, Bridgewater, NJ, USA; GenAqua®, Novartis Ophthalmics, East Hanover, NJ, USA; Tears Again®, OcuSoft; Vizulize Dry Eyes Eye Mist, Butterflies Healthcare, Banbury, OX, UK; Bio-Logic Aqua®, Bio-Logic Aqua Technologies.
Abbreviations: BAK, benzalkonium chloride; CMC, carboxy methylcellulose; HPMC, hydroxypropyl methylcellulose; N-IG, N-hydroxymethylglycinate; PVA, polyvinyl alcohol.