Table 1.
Patient Characteristics & Islet Isolation Results
| Patient 1 | Patient 2 | Patient 3 | |
|---|---|---|---|
| Sex (M/F), Age (yrs), BMI (kg/m2) | Female, 16, 26.4 | Male, 12, 18.3 | Female, 28, 20.8 |
| Cause of Pancreatitis | Unknown | Familial | Sphincter of Oddi dysfunction |
| Pancreas Weight | 59 | 107 | 39 |
| Condition of Pancreas | Rock-like, low fat, medium blood content | Rock-like, medium fat, high blood content | Rock-like, medium fat, medium blood content |
| Condition of Ducts | Intraductal stones | Dilated duct | Dilated duct |
| Digestion Time (min) | 64 | 32 | 37 |
| Dilution Time (min) | 5 | 24 | 20 |
| Undigested Pancreas (%) | 40 | 61 | 90 |
| Postdigest IEQ (103) | 4.13 | 111.98 | 10.28 |
| Postdigest IEQ/g Pancreas | 70 | 1047 | 265 |
| Postdigest IEQ/Islet Number | 0.3 | 0.7 | 0.5 |
| Embedded Islet (%) | 60 | 50 | 75 |
| Islet Viability (FDA/PI; %) | ND | 83.4 | 94.2 |
| Final Product Purity (%) | ND | 30 | 10 |
| Final Tissue Volume (mL) | 1.5 | 3.0 | 2.0 |
| Post-operative insulin use | Dependent | Independent | Dependent |
| HbA1c (after surgery, %) | 9.3 | 5.3 – 6.0 | 7.5 – 8.5 |
| C-peptide (after surgery, ng/mL) | n/a | 0.8 – 4.9 | <0.1 – 0.3 |
BMI, body mass index; IEQ, islet equivalent; Percent recovery, postpurification IEQ/postdigest IEQ × 100; FDA, fluorescein diacetate; PI, propidium iodide