Table 1.
Institutional Context and Outcomes for the Nine Benchmarked Centers
| Center | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| A | B | C | D | E‡ | F | G | H | I | |
| Number of CF Patients (% Adult) | 297 (38.9) | 165 (54.0) | 369 (39.1) | 231 (39.9) | 101 (41.2) | 454 (54.5) | 450 (54.4) | 326 (61.0) | 264 (54.2) |
| Separate Adult and Pediatric Institutions | Yes | No | No | Yes | No | No | No | No | No |
| Combined Adult/Pediatric Research Support Staff | No* | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
| CF Translational Research Focus|| | ++ | + | +++ | + | - | +++ | ++ | +++ | ++ |
| Staff Travel Time (Minutes) to Research Visit Location | 5 | 0 | 0 | 5 | 0 | 15 | 5 | 0 | 10 |
| Estimated FTE for Research Support Staff† | 4.6 | 1.5 | 3.8 | 5.0 | 1.6 | 3.5 | 4.0 | 5.0 | 5.0 |
| Number of Research Staff per 100 Patients with CF at Site | 1.5 | 0.9 | 1.0 | 2.2 | 1.6 | 0.8 | 0.9 | 1.5 | 1.9 |
| Average Quartile Time to IRB Approval§ | 2.5 | 2.6 | 2.5 | 2.8 | 3.8 | 2.9 | 2.5 | 1.8 | 3.3 |
| Average Quartile Time to Contract Execution§ | 3.3 | 3.5 | 2.2 | 2.4 | 3.0 | 2.3 | 2.6 | 2.2 | 1.7 |
| Average Quartile Time to Activation§ | 2.7 | 3.3 | 2.3 | 2.8 | 3.2 | 3.0 | 2.4 | 1.8 | 2.4 |
| Average Quartile Time to First Patient Enrolled§ | 3.3 | 2.7 | 2.2 | 3.1 | 3.0 | 2.2 | 2.4 | 2.5 | 2.7 |
*The pediatric research team was the primary focus of the review because at the time of the benchmarking, adult subjects were recruited by the pediatric research team and were seen at the pediatric center for research visits
†Research support staff included research managers, research coordinators (both nurse and non-nurse), laboratory staff, regulatory document coordinators, budget and contract support. All teams had some dedicated CF clinical research staff, while some teams also had institutional support for various functions (for which FTE was estimated). There was variation within each research team regarding the specific personnel and who performed which function
‡Center E was not a CTSA Awardee
§ The average quartile time presented in this table comes from Period 2 (10/1/2008 – 3/31/2010). For comparison, the average quartile time for the 23 CTSA sites that were not benchmarked was 2.1 or 2.2 for all milestones
||Centers were categorized as having no (−), limited (+), moderate (++), or significant (+++) translational focus based on the amount of basic and investigator-initiated CF research being conducted at the institution