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Parameter Estimates for Sensitivity Analysis
| Parameters | Base-case | Low | High |
|---|---|---|---|
| Fixed financial costs (C f)* | $1,000,000 | $500,000 | $2,000,000 |
| Variable financial costs (C v)* | 5,000 | 2,500 | 10,000 |
| Enrolment fraction (f) | 20 % | 15 % | 25 % |
| Time horizon (h) | 20 years | 15 years | 25 years |
| Discount rate | 0 % | 3 % | 5 % |
| FVIII unit cost | 0.50 cent | – | 0.75 cent, 1.00USD |
*Cost estimates were taken from the Canadian tailored prophylaxis study. All costs are in U.S. dollars
