Table 2.
Full gene name (Official gene symbol) | Probe set ID | Log 2 expression of Ts1Cje normalized against disomic littermates | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cerebral cortex | Cerebellum | Hippocampus | |||||||||||
P1 | P15 | P30 | P84 | P1 | P15 | P30 | P84 | P1 | P15 | P30 | P84 | ||
RIKEN cDNA 1110004E09Rik gene (1110004E09Rik) | 1424315_at | 0.72 | 0.70 | 0.67 | 0.73 | 1.39* | 0.91 | 0.91 | 0.70 | 0.61 | 1.12 | 0.97 | 0.83 |
RIKEN cDNA 2410124H12Rik gene (2410124H12Rik) | 1432515_at | 0.03 | 0.09 | 0.01 | 0.16 | 0.07 | 1.68** | 1.51*** | 2.26*** | -0.02 | -0.08 | 0.05 | -0.14 |
ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (Atp5o) | 1416278_a_at | 0.65 | 0.49 | 0.70 | 0.48 | 0.43 | 0.67 | 0.82* | 0.54 | 0.68 | 0.37 | 0.48 | 1.09*** |
1437164_x_at | 0.58 | 0.71 | 0.72* | 0.64 | 0.68* | 0.74** | 0.78** | 0.59 | 0.71* | 0.64* | 0.74* | 0.94*** | |
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 (B3galt5) | 1450528_at | 0.00 | 0.02 | -0.02 | 0.00 | 0.02 | 0.15 | -0.01 | 0.43 | -0.02 | -0.11 | 0.15 | 1.25* |
Expressed sequence BF642829 (BF642829) | 1435484_at | 0.56 | 0.34 | 0.68 | -0.04 | 0.91** | 0.75* | 0.68 | 0.01 | 0.59 | 0.69 | 0.89** | 0.17 |
Bromodomain and WD repeat domain containing 1 (Brwd1) | 1427322_at | 0.67 | 0.45 | 0.50 | 0.40 | 0.32 | 0.81* | 0.84* | 0.54 | 0.78 | 0.26 | 0.52 | 1.11*** |
1433955_at | 0.55 | 0.53 | 0.63 | 0.86* | 1.17*** | 0.81** | 0.57 | 1.01*** | 0.39 | 0.70* | 0.70* | 0.91*** | |
1452322_a_at | 0.07 | 0.62 | 0.47 | 0.83* | 0.14 | 0.37 | 0.22 | 0.94*** | 0.67* | 0.46 | 0.68* | 0.22 | |
C2 calcium-dependent domain containing 2 (C2cd2) | 1436344_at | 0.47 | 0.47 | 0.38 | 0.54 | 0.27 | 1.87*** | 0.47 | 0.74 | 0.39 | 0.71 | 0.91 | 0.68 |
1437731_at | 0.79 | 0.30 | 0.15 | 0.47 | 0.59 | 1.21* | 0.18 | 0.45 | 0.58 | 0.32 | 0.55 | 0.18 | |
Carbonyl reductase 1 (Cbr1) | 1460196_at | 0.67 | 0.48 | 0.66 | 0.58 | 0.71 | 0.52 | 0.30 | 0.72* | 0.64 | 0.95** | 0.72 | 0.74* |
Carbonyl reductase 3 (Cbr3) | 1427912_at | 1.55 | 1.11 | 0.82 | 0.81 | 1.08 | -0.02 | 0.21 | 0.79 | 1.24 | 2.04* | 1.07 | 0.44 |
Chromatin assembly factor 1, subunit B (p60) (Chaf1b) | 1423877_at | 1.15*** | 0.10 | 0.00 | 0.08 | 0.93*** | -0.03 | -0.06 | 0.00 | 1.51*** | 0.05 | -0.08 | -0.11 |
Crystallin, zeta (quinone reductase)-like 1 (Cryzl1) | 1430547_s_at | 0.70 | 0.57 | 0.76 | 0.55 | 0.60 | 0.70 | 0.97 | 0.94* | 0.57 | 0.17 | 0.37 | 1.28*** |
1451473_a_at | 0.47 | 0.61 | 0.86** | 0.67 | 0.61 | 0.88*** | 0.49 | 0.51 | 0.57 | 0.82** | 0.85** | 0.59* | |
DnaJ (Hsp40) homolog, subfamily C, member 28 (Dnajc28) | 1420542_at | 0.36 | 0.29 | 0.14 | 0.18 | 0.26 | 0.33 | 0.21 | 0.81* | 0.28 | 0.15 | 0.26 | 0.23 |
Downstream neighbor of SON (Donson) | 1426739_at | 0.76 | 0.72 | 0.91** | 0.78 | 0.82* | 0.91** | 0.75 | 0.75* | 0.81* | 0.65 | 0.63 | 0.92** |
Dopey family member 2 (Dopey2) | 1428330_at | 0.68* | 0.47 | 0.61 | 0.45 | 0.58 | 0.83** | 0.70* | 0.59 | 1.00*** | 0.68* | 0.85** | 0.77** |
Down syndrome cell adhesion molecule (Dscam) | 1441082_at | 0.35 | 0.70 | 1.13 | 0.78 | 0.41 | 0.36 | 0.94 | 0.74 | 0.40 | 1.60** | 1.13 | 0.59 |
1449411_at | 0.94 | 0.83 | 0.98 | 1.03 | 0.69 | 0.54 | 0.70 | 1.22* | 0.81 | 1.52** | 0.87 | 0.86 | |
1458625_at | 0.52 | 0.44 | 0.74 | 0.72 | 0.79 | 0.11 | 0.33 | 0.50 | 0.72 | 1.65*** | 1.39** | 0.45 | |
Down syndrome critical region 3 (Dscr3) | 1415745_a_at | 0.87 | 0.74 | 0.66 | 0.91 | 0.97* | 0.93* | 0.87 | 0.66 | 0.80 | 0.89* | 1.01* | 0.94* |
E26 avian leukemia oncogene 2, 3' domain (Ets2) | 1416268_at | 0.78 | 0.62 | 0.81 | 0.56 | 0.54 | 0.87* | 0.65 | 0.80* | 0.62 | 0.45 | 0.68 | 0.77 |
Phosphoribosylglycinamide formyltransferase (Gart) | 1416283_at | 0.52 | 0.38 | 0.92 | 0.37 | 0.39 | 1.17** | 0.54 | 0.93 | 0.70 | 0.95 | 1.20* | 0.95 |
1424436_at | 0.41 | 0.85 | 0.70 | 0.98 | 0.98 | 1.03* | 0.20 | 1.30*** | 0.18 | 0.93 | 0.69 | 0.67 | |
High mobility group nucleosomal binding domain 1 (Hmgn1) | 1422495_a_at | 0.51 | 0.60 | 0.59 | 0.55 | 0.22 | 0.96** | 0.49 | 0.68* | 0.36 | 0.16 | 0.64 | 0.82** |
1438940_x_at | 0.39 | 0.52 | 0.50 | 0.67 | 0.40 | 0.76* | 0.24 | 0.54 | 0.39 | 0.33 | 0.50 | 0.36 | |
1455897_x_at | 0.44 | 0.69 | 0.70 | 0.95 | 0.49 | 1.07** | 0.30 | 0.80 | 0.40 | 0.52 | 0.87 | 0.58 | |
Hormonally upregulated Neu-associated kinase (Hunk) | 1418260_at | 0.66 | 0.66 | 0.25 | 0.68 | 0.41 | 0.83 | 0.87 | 0.64 | 1.10* | 0.52 | 0.61 | 1.16** |
Interferon (alpha and beta) receptor 1 (Ifnar1) | 1442222_at | 0.63 | 0.74 | 1.05 | 0.77 | 0.45 | 1.12* | 0.73 | 0.68 | 0.62 | 0.80 | 0.80 | 0.75 |
1449026_at | 0.80 | 0.80 | 1.17* | 1.29* | 0.55 | 0.67 | 0.85 | 1.10* | 0.46 | 1.12* | 0.84 | 0.75 | |
Interferon (alpha and beta) receptor 2 (Ifnar2) | 1427691_a_at | 0.66 | 0.52 | 0.67 | 0.40 | 0.55 | 0.80 | 0.48 | 0.58 | 0.73 | 1.49* | 0.91 | 0.50 |
1440169_x_at | 0.72 | 0.92 | 0.78 | 0.60 | 0.89 | 0.68 | 0.45 | 0.34 | 1.22 | 1.49* | 0.84 | 0.62 | |
1451462_a_at | 0.70 | 0.90 | 0.99* | 0.98 | 0.61 | 0.90* | 0.80 | 0.93* | 0.81 | 0.83 | 0.92* | 1.43*** | |
Interferon gamma receptor 2 (Ifngr2) | 1423558_at | 0.31 | 0.39 | 0.40 | 0.44 | 0.67** | 0.14 | 0.17 | 0.21 | 0.21 | 0.45 | 0.28 | 0.26 |
Intersectin 1 (SH3 domain protein 1A) (Itsn1) | 1421192_a_at | 0.82 | 0.45 | 0.90 | 0.40 | 0.03 | 0.94* | 1.16** | 0.66 | 1.01* | 0.48 | 0.97* | 1.04** |
1425899_a_at | 0.58 | 0.61 | 0.71 | 0.22 | 0.35 | 0.72 | 1.37 | 0.90 | 0.76 | -0.54 | 0.18 | 1.67* | |
1435885_s_at | 0.56 | 0.61 | 0.63 | 0.66** | 0.46 | 1.18* | 0.25 | 0.50 | 0.49 | 0.37 | 0.97 | 0.21 | |
1452338_s_at | 0.58 | 0.96 | 1.42** | 1.66 | 0.44 | 0.99 | 0.80 | 1.30** | 0.64 | 0.25 | 0.70 | 0.74 | |
Potassium inwardly-rectifying channel, subfamily J, member 6 (Kcnj6) | 1425707_a_at | -0.13 | 0.24 | 0.22 | 0.59 | 0.18 | 0.29 | 0.04 | 0.31 | -0.21 | 0.57 | 1.07* | -0.06 |
Microrchidia 3 (Morc3) | 1420091_s_at | 0.55 | 0.81** | 0.64 | 0.66 | 0.78** | 0.84*** | 0.69* | 0.55 | 0.64* | 0.66* | 0.78** | 0.99*** |
1452224_at | 0.69 | 0.64 | 0.68 | 0.66 | 0.82 | 0.99 | 1.21* | 0.52 | 1.20* | 0.51 | 0.55 | 1.45** | |
Mitochondrial ribosomal protein S6 (Mrps6) | 1424440_at | 0.84** | 0.62 | 0.73 | 0.35 | 0.89** | 0.70* | 0.89** | 1.00*** | 0.77* | 0.72* | 0.64 | 0.91** |
1447585_s_at | 0.93 | 0.74 | 0.88 | 0.74 | 1.13* | 0.88 | 0.53 | 0.94 | 0.61 | 1.15* | 0.91 | 0.61 | |
PAX3 and PAX7 binding protein 1 (Paxbp1) | 1418007_at | 0.55 | 0.66 | 0.75 | 0.59 | 0.55 | 1.32* | 0.59 | 0.80 | 0.83 | 0.15 | 0.80 | 0.56 |
1418008_at | 0.46 | 0.38 | 0.74 | 0.62 | 0.56 | 1.45* | 0.63 | 0.75 | 0.92 | 0.21 | 0.92 | 0.86 | |
Phosphatidylinositol glycan anchor biosynthesis, class P (Pigp) | 1436038_a_at | 0.69* | 0.70 | 0.77* | 0.95** | 0.77** | 0.75** | 0.84** | 0.82*** | 0.38 | 0.54 | 0.55 | 1.16*** |
PR domain containing 15 (Prdm15) | 1455459_at | 0.41 | -0.04 | 0.47 | 0.59 | 0.21 | 0.37 | 0.59 | 0.18 | 0.44 | 0.48 | 0.35 | 0.95* |
Proteasome (prosome, macropain) subunit, alpha type 2 (Psmg1) | 1448307_at | 0.81* | 0.52 | 0.78 | 0.97* | 0.73 | 0.99** | 0.57 | 0.88** | 0.55 | 1.04** | 0.82* | 0.94** |
Regulator of calcineurin 1 (Rcan1) | 1416600_a_at | 0.98* | 0.74 | 0.89 | 0.43 | 0.89 | 0.71 | 0.70 | 0.76 | 0.73 | 1.10** | 0.84 | 0.68 |
Receptor-interacting serine-threonine kinase 4 (Ripk4) | 1418488_s_at | 0.06 | 0.07 | 0.00 | 0.12 | 0.12 | -0.02 | 0.06 | 0.02 | 0.53*** | 0.02 | -0.05 | -0.09 |
Solute carrier family 5 (inositol transporters), member 3 (Slc5a3) | 1435484_at | 0.56 | 0.34 | 0.68 | -0.04 | 0.91*** | 0.75*** | 0.68 | 0.01 | 0.59 | 0.69 | 0.89*** | 0.17 |
Small integral membrane protein 11(Smim11) | 1417402_at | 0.85 | 0.43 | 0.64 | 0.40 | 0.90* | 0.69 | 0.59 | 0.59 | 0.77 | 0.37 | 0.68 | 0.70 |
Son cell proliferation protein (Son) | 1420952_at | 0.68 | 0.69 | 0.90 | 0.86 | 0.36 | 1.28* | 0.71 | 0.87 | 0.88 | 0.54 | 0.77 | 0.65 |
1435862_at | 0.64 | 0.75 | 0.80 | 0.63 | 0.35 | 1.04** | 1.24*** | 0.78 | 0.99* | 0.20 | 0.58 | 1.17** | |
1437924_at | 0.63 | 0.62 | 0.79 | 0.82 | 0.28 | 0.96** | 0.75 | 0.67 | 0.35 | 0.60 | 0.65 | 0.73 | |
Synaptojanin 1 (Synj1) | 1436333_a_at | 0.67 | 0.65 | 0.77 | 0.84 | 0.89 | 0.57 | 0.74 | 0.84 | 0.74 | 1.38* | 0.79 | 0.72 |
1454961_at | 0.60 | 0.57 | 0.65 | 0.63 | 0.57 | 0.43 | 0.58 | 0.71* | 0.56 | 0.86** | 0.55 | 0.67 | |
Transmembrane protein 50B (Tmem50b) | 1423707_at | 0.78** | 0.51 | 0.70* | 0.46 | 0.83** | 0.69* | 1.07*** | 0.71** | 0.96*** | 0.76** | 0.84** | 0.99*** |
Tetratricopeptide repeat domain 3 (Ttc3) | 1416484_at | 0.52 | 0.53 | 0.68 | 0.56 | 0.60 | 0.39 | 0.74 | 0.87* | 0.53 | 0.31 | 0.26 | 0.78 |
1448361_at | 0.45 | 0.45 | 0.54* | 0.43 | 0.21 | 0.43 | 0.46 | 0.40 | 0.33 | 0.63** | 0.45 | 0.46 | |
URB1 ribosome biogenesis 1 homolog (S. cerevisiae) (Urb1) | 1454841_at | 0.58 | 0.49 | 0.77 | 0.46 | 0.24 | 0.16 | 0.48 | 0.37 | 0.98* | 0.62 | 0.76 | 0.85 |
Tryptophan rich basic protein (Wrb) | 1460446_at | 0.62 | 0.64 | 0.63 | 0.74 | 0.72* | 0.90* | 0.45 | 0.67* | 0.56 | 0.85** | 0.69 | 0.70* |
*p<0.05, **p<0.01 and ***p<0.001 based on Empirical Bayes t-statistic test.