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. 2014 Jul 28;15(1):630. doi: 10.1186/1471-2164-15-630

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© Wang et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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SR protein and ESE functions for the bovine CD46 gene. The SR protein containing the serine-arginine residue (RS) domain and RNA recognition motif (RRM) is depicted as interacting with the exonic splicing enhancer (ESE). The SNP locates in the ESE. The U1 (green) and U2 (blue) spliceosomal snRNPs and the two small subunits of the U2AF auxilliary factors (U2AF65 and U2AF35) are required for ESE-dependent splicing.