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. 2014 Jul 29;15(1):255. doi: 10.1186/1471-2105-15-255

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© Wang et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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A case study on the miR-34a overexpressed HCT116 cells. (A) Fold change of all genes and miR-34a targets. The p-value is estimated by K-S test. (B) Fold change and NPES score of miR-34a targets. Blue dot represents the absolute value of gene expression fold change, which is normalized by the maximum of all genes; Green dot represents the NPES computed by using single target as the RWR seed in the step 1 of forward searching, and all the miRNA targets are sorted according to this score; Red dot stands for the NPES generated by using multiple targets as the RWR seed, the peak value is the optimal score and those targets appearing at and before this point are the leading-edge targets. (C) Neighbor sub-network of the miR-34a target CUX1. Gene name and expression fold change are labeled in each node.