Table 1.
Summary of CTC counts in 7.5 mL of blood from patients (n) with various types of metastatic carcinomas. It represents the percentage of patients (%) from the total group of patients (n) above a certain CTC cut-off, detected with the CellSearch System.
| % (n) ≥ 1 | % (n) ≥ 2 | % (n) ≥ 3 | % (n) ≥ 5 | % (n) ≥ 10 | % (n) ≥ 50 | % (n) ≥ 100 | References | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Subject | |||||||||||||||
| Healthy | 2 | (330) | 0.3 | (330) | 0 | (185) | 0 | (330) | 0 | (330) | 0 | (330) | 0 | (330) | [4, 13, 47–49] |
| Nonmalignant | 5 | (398) | 1 | (398) | 0 | (101) | 0 | (101) | 0 | (101) | 0 | (101) | 0 | (101) | [4, 47] |
|
| |||||||||||||||
| Metastatic cancer type | |||||||||||||||
| Bladder | 47 | (53) | 35 | (20) | — | 25 | (53) | 5 | (20) | 0 | (20) | 0 | (53) | [50, 51] | |
| Breast | 55 | (200) | 53 | (562) | 33 | (91) | 38 | (671) | 32 | (562) | 18 | (268) | 12 | (562) | [4, 47, 52–55] |
| Colorectal | 48 | (545) | 34 | (455) | 32 | (676) | 18 | (455) | 12 | (455) | 0 | (42) | 0 | (455) | [8, 56–59] |
| Gastric | 67 | (27) | 56 | (27) | 41 | (27) | 26 | (27) | 19 | (27) | 4 | (27) | 4 | (27) | [13] |
| Lung, non-small cell | 46 | (57) | 28 | (117) | 20 | (20) | 11 | (57) | 10 | (20) | 5 | (20) | 5 | (20) | [53, 60, 61] |
| Lung, small cell | 95 | (38) | 89 | (62) | 79 | (38) | 79 | (38) | 74 | (38) | 53 | (38) | 47 | (38) | [12, 62] |
| Ovarian | — | 14 | (216) | — | — | — | — | — | [15] | ||||||
| Pancreatic | 35 | (72) | 19 | (72) | 15 | (72) | 8 | (72) | 7 | (72) | 3 | (72) | 3 | (72) | [63, 64] |
| Prostate | 60 | (149) | 80 | (40) | 66 | (95) | 59 | (314) | 53 | (40) | 33 | (40) | 18 | (40) | [10, 48, 49, 53, 65, 66] |