Table 3.
Univariate analysis: factors predictive of sustained virological response in cirrhotic patients with genotype 1b
| Factor | Value (range or number) | ||
|---|---|---|---|
| SVR n = 11 |
Non-SVR n = 64 |
P value | |
| Sex (male/female) (cases) | 5/6 | 28/36 | 0.916 |
| Mean age/range (years) | 62.5 ± 9.2 | 61.6 ± 8.6 | 0.664 |
| White blood cells (/mm3) | 4,042.7 ± 1,377.4 | 3,930.0 ± 1,154.8 | 0.811 |
| Hemoglobin (g/dl) | 13.1 ± 1.4 | 12.9 ± 1.8 | 0.632 |
| Platelet count (×104/mm3) | 10.6 ± 2.8 | 9.4 ± 3.7 | 0.185 |
| AST (IU/l) | 86.8 ± 4.3 | 63.0 ± 33.0 | 0.119 |
| ALT (IU/l) | 112.6 ± 92.9 | 66.5 ± 38.0 | 0.027 |
| AST/ALT | 0.85 ± 0.17 | 1.04 ± 0.27 | 0.022 |
| Total bilirubin (mg/dl) | 0.9 ± 0.4 | 1.0 ± 0.4 | 0.306 |
| Albumin (g/dl) | 4.0 ± 0.4 | 3.8 ± 0.4 | 0.382 |
| PT percentage activity (%) | 88.4 ± 11.6 | 82.1 ± 9.3 | 0.137 |
| Associated esophageal varices (cases) (present/absent) | 3/8 | 44/20 | 0.009 |
| History of treatment for HCC (cases) (with or without) | 2/9 | 19/45 | 0.432 |
| Previous treatment of IFN (cases) (with or without) | 6/5 | 38/26 | 0.764 |
| HCV-RNA (KIU/ml) | |||
| Low level (<1,000 KIU/ml) (cases) | 2 | 20 | |
| High level (≥1,000 KIU/ml) (cases) | 9 | 44 | 0.379 |
| ISDR (wild type/non-wild type)/ND | 7/3/1 | 53/9/2 | 0.223 |
| Core aa 70 [arginine/glutamine (histidine)]/ND | 5/5/1 | 33/30/1 | 0.889 |
| Core aa 91 (leucine/methionine)/ND | 8/2/1 | 46/17/1 | 0.640 |
| IL28B (rs 8099917) TT/TG or GG/ND | 10/1/0 | 35/26/3 | 0.035 |
AST Aspartate aminotransferase, ALT alanine aminotransferase, AST/ALT aspartate aminotransferase/alanine aminotransferase ratio, ND not determined