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. 2006 May 21;12(19):3065–3072. doi: 10.3748/wjg.v12.i19.3065

Table 1.

Incidences of liver tumors caused by exposure to aflatoxin B1 (AFB1) and cyanobacterial toxins (CT) alone or in combination in HBV x (HBVx) gene transgenic mice and their wild-type littermates at 24 wk post-treatment

Group Treatments
n Adenoma (%) Carcinoma (%) Total (%)
HBVx gene AFB1 CT
1 - - - 40 0 (0) 0 (0) 0 (0)
2 + - - 10 0 (0) 0 (0) 0 (0)
3 - + - 20 1 (5.0) 0 (0) 1 (5.0)
4 + + - 11 1 (9.1) 0 (0) 1 (9.1)
HBVx gene AFB1 MC-LR
5 - - + 26 1 (3.9) 0 (0) 1 (3.9)
6 + - + 11 0 (0) 0 (0) 0 (0)
7 - + + 21 2 (9.5) 2 (9.5) 4 (19.0)a
8 + + + 15 2 (13.3) 1 (6.7) 3 (20.0)a
HBVx gene AFB1 NOD
9 - - + 26 0 (0) 0 (0) 0 (0)
10 + - + 11 0 (0) 0 (0) 0 (0)
11 - + + 9 2 (22.2) 1 (11.1) 3 (33.3)b,c
12 + + + 11 4 (36.4) 0 (0) 4 (36.4)d,e,f

MC-LR: Microcystin-LR; NOD: nodularin. aP < 0.05 vs group 1, bP < 0.01 vs group 1, cP < 0.05 vs group 9, dP < 0.01 vs group 1, eP < 0.05 vs group 3, fP < 0.01 vs group 9.