Figure 2. The effect of p27^kip1 haplo-insufficiency on the expression of VEGF, HGF and their activated receptors.

(a) Representative immunoblots of VEGF, Phospho-KDR, HGF and phospho-Met in the LV of p27^+/− or WT mice 28 d after treatment with sham or MI operations, according to its 43 KDa molecular weight, the up-regulated VEGF-A165 was confirmed. GAPDH served as the loading control. Quantification is shown, *p < 0.05 vs. WT sham; #p < 0.05 vs. WT MI (n = 3) (b) Histochemical staining of phospho-KDR in endothelial cells (upper panel) and phospho-Met in cardiomyocytes (lower panel) in mouse hearts after sham (left panel) or MI (right panel) operations.