Figure 8.

Illustration of the effects of coupling selected numbers of myofibroblasts to 1 human atrial myocyte using an in silico hybrid model similar to the one first described by Maleckar et al. (2009a), assuming a myofibroblast resting potential of −65 mV. The layout of this Figure is the same as that of Figure 7. Note that two potentially important differences in the patterns of in silico responses were obtained: (1) in all situations, the myofibroblast electrotonic responses are larger, (2) the myofibroblasts exert only a minimal depolarizing influence on the resting potential of the atrial myocyte.