Table 2. Association of QT SNPs with gene expression in human left ventricle.

Shown are QT SNPs associated with expression of a transcript within 1Mb at experiment-wide significance (Supplementary Note). For each transcript, the best eSNP for that transcript is shown. The QT SNP association with transcript is shown with and without adjustment for the best eSNP for that transcript. QT SNPs and transcripts are bolded if the QT SNP and best eSNP are highly correlated (r² > 0.8), show attenuation of association in conditional models and show comparable strength of association with QT interval for both the QT SNP and best eSNP.

QT SNP	chr	position	transcript	best eSNP for transcript	r2 between QT SNP & eSNP	direction of eSNP effect for QT increasing allele	Transcript association of QT SNP (P)	Transcript association of QT SNP with adjustment for best eSNP (P)	attenuated significance	QT association of QT SNP (P)	QT association of best eSNP (P)
rs17457880	1	160,434,778	FCGR2B	rs17457880	same	↑	1×10-5	0.99	YES	3×10-10	same
rs17457880	1	160,434,778	FCGR3A	rs9727076	0.00	↑	1×10-7	9x10-9	NO	3×10-10	NA
rs295140	2	200,868,944	SPATS2L	rs295113	0.53	↓	8×10-7	0.74	YES	4×10-13	0.76
rs174583	11	61,366,326	FADS2	rs174548	0.80	↓	6×10-8	0.94	YES	1×10-10	8×10-8
rs3026445	12	109,207,586	VPS29	rs6606686	0.86	↑	1×10-6	0.84	YES	1×10-8	2×10-7
rs728926	13	73,411,123	KLF12	rs1886512	0.93	↑	4×10-5	0.25	YES	2×10-8	4×10-8
rs735951	16	11,601,037	LITAF	rs7187498	0.93	↑	4×10-13	0.62	YES	2×10-28	NA
rs246196	16	57,131,754	SETD6	rs42945	0.30	↑	4×10-7	0.20	YES	2×10-57	9×10-22
rs9892651	17	61,734,255	PRKCA	rs11658550	0.97	↑	2×10-41	0.22	YES	3×10-14	NA