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. 2013 Oct 8;8(1):83–92. doi: 10.1016/j.molonc.2013.09.004

Figure 4.

Figure 4

ATM expression is suppressed in oxaliplatin‐resistant CRC cells. A. Illustration of the two in silico predicted miR‐203 targeting sites in the ATM 3′UTR region. B. HT29‐OxR and HCT116‐OxR cells express significantly decreased ATM mRNA levels compared with the levels expressed by their chemo‐naïve parental cell lines as measured by qPCR. C. HT29‐OxR and HCT116‐OxR cells express decreased ATM protein levels compared from those expressed by their chemo‐naïve parental (Par) cell lines by Western blotting. *P < 0.05. Results are representative of three experiments.