FIG. 4.

Monitoring antiviral immune responses. Adaptive immune response against systemically administered VSV-hIFNβ-NIS was monitored by measuring anti-VSV neutralizing antibodies in serum collected at the indicated times. (A) Anti-VSV neutralizing antibodies in serum were detected by plaque reduction neutralization assay. Anti-VSV antibody titer indicates the minimum serum dilution that did not protect Vero cells from in vitro VSV infection. (B). Anti-VSV IgG and IgM antibodies were detected in serum by ELISA. Values are shown relative to baseline (pretreatment) values. IgG, immunoglobulin G; IgM, immunoglobulin M.