TABLE 2.
Biopsy characteristics of men with Gleason 8 – 10 prostate cancer with favourable (pT2 – pT3a) and unfavourable (pT3b or N1) pathology
| Biopsy Gleason 8 – 10 | Favourable | Unfavourable | P | |
|---|---|---|---|---|
| N (%): | 842 | 656 (77.9) | 186 (22.1) | |
| Biopsy Gleason: | ||||
| 8 | 602 (71.5) | 507 (77.3) | 95 (51.1) | |
| 3 + 5 | 54 (6.4) | 48 (7.3) | 6 (3.2) | |
| 4 + 4 | 414 (49.2) | 353 (53.8) | 61 (32.8) | |
| 5 + 3 | 14 (1.7) | 11 (1.7) | 3 (1.6) | < 0.001 |
| 9 | 228 (27.1) | 143 (21.8) | 85 (45.7) | |
| 4 + 5 | 138 (16.4) | 98 (14.9) | 40 (21.5) | |
| 5 + 4 | 45 (5.3) | 25 (3.8) | 20 (10.8) | |
| 10, 5 + 5 | 12 (1.4) | 7 (1.1) | 5 (2.7) | |
| Positive cores: | ||||
| Median (range) | 4 (1 – 16) | 3 (1 – 15) | 4.5 (1 – 16) | < 0.001 |
| 1 – 3, n (%) | 321 (49.2) | 273 (52.2) | 48 (36.9) | 0.002 |
| >, n (%)3 | 332 (50.8) | 250 (47.8) | 82 (63.1) | |
| High-grade cores: | ||||
| Median (range) | 2 (1 – 16) | 2 (1 – 10) | 2 (1 – 16) | < 0.001 |
| >1, n (%) | 353 (54.4) | 263 (50.3) | 90 (69.2) | < 0.001 |
| Total cores, median (range) | 12 (3 – 60) | 12 (3 – 60) | 12 (4 – 18) | 0.001 |
| Percentage cores positive, median (range) | 40 (5 – 100) | 31 (5 – 100) | 54 (8 – 100) | < 0.001 |
| PPC: | ||||
| Median (range) | 70 (5 – 100) | 60 (5 – 100) | 90 (25 – 100) | 0.065 |
| 0 to <50%, n (%) | 196 (30.3) | 181 (34.7) | 15 (12.0) | < 0.001 |
| ≥50 to 100%, n (%) | 450 (69.7) | 340 (65.3) | 110 (88.0) | |
| N (%): | ||||
| Positive core laterality: | ||||
| Bilateral | 209 (46.8) | 159 (25.6) | 50 (30.5) | |
| Right | 118 (26.4) | 98 (15.8) | 22 (13.4) | 0.4 |
| Left | 120 (26.8) | 98 (15.8) | 20 (12.2) | |
| Positive core location | ||||
| Apex | 254 (77.2) | 197 (75.8) | 57 (82.6) | 0.2 |
| Mid-gland | 258 (78.4) | 198 (76.2) | 60 (87.0) | 0.06 |
| Base | 237 (72.0) | 174 (66.9) | 63 (91.3) | < 0.001 |
| histologic features on biopsy: | ||||
| PNI | 207 (30.4) | 147 (26.9) | 60 (44.1) | < 0.001 |
| Atypia | 94 (13.8) | 77 (14.1) | 17 (12.5) | 0.6 |
| HGPIN | 108 (15.8) | 94 (17.2) | 14 (10.3) | 0.048 |
HGPIN, high-grade prostatic intraepithelial neoplasia; PNI, perineural invasion; PPN, maximum percentage involvement of each positive core.