Table 2.
Metabolic data of mice in different groups by time.
| 16 weeks | 20 weeks | 25 weeks | ||||
|---|---|---|---|---|---|---|
| C | DN | C | DN | C | DN | |
| BW (mg) | 22.80 ± 2.52 | 47.86 ± 0.83** | 22.54 ± 1.24 | 52.26 ± 2.47** | 23.26 ± 0.67 | 47.52 ± 2.56** |
| RBG (mmol/L) | 4.48 ± 0.71 | 12.33 ± 1.67** | 4.78 ± 0.84 | 24.15 ± 1.62∗∗△ | 5.92 ± 0.87 | 33.08 ± 1.54∗∗△ |
| UAE (μg/24 h) | 27.68 ± 1.65 | 386.12 ± 16.30** | 24.20 ± 1.45 | 452.12 ± 32.26∗∗△ | 27.24 ± 1.52 | 551.78 ± 29.19∗∗△△ |
| BUN (mmol/L) | 8.32 ± 0.37 | 9.38 ± 0.29* | 8.56 ± 0.43 | 9.94 ± 0.20** | 8.44 ± 0.45 | 10.48 ± 0.18∗∗△ |
| Scr (mmol/L) | 14.80 ± 0.58 | 28.2 ± 1.7 | 18.00 ± 1.30 | 33.60 ± 3.37** | 16.60 ± 1.67 | 25.40 ± 2.77** |
Data are means ± SEM. C: control; DN: diabetic nephropathy; BW: body weight; UAE: urinary albumin excretion; BUN: blood urea nitrogen; Scr: serum creatinine.
*P < 0.05, **P < 0.01 versus age-matched control mice.
△ P < 0.05, △△ P < 0.01 versus 16-week-old db/db mice.