FIGURE 1.

An overview of alterations in striatal proteostasis pathways. Protein quality control in neurons is accomplished through three major pathways: the UPS, chaperones and the heat shock response, and autophagy. Recent work indicates that striatal neurons may express and induce the proteins involved in these pathways differently than other cell types. Listed findings were performed in HD and wild-type model systems as follows: (1) primary striatal neuron, (2) HD mouse striatum, (3) wild-type mouse striatum, (4) human HD striatum.