mTOR inhibition |
Autophagy induction |
Cell line, fly, mouse |
Cellular toxicity, mHtt aggregation, motor phenotypes, weight gain |
Ravikumar et al. (2004), Berger et al. (2006)
|
IMPase inhibition |
Autophagy induction |
Cell line |
Cellular toxicity, mHtt levels |
Sarkar et al. (2005) |
Calpain inhibition |
Autophagy induction |
Cell line, zebrafish |
Cellular toxicity, mHtt aggregation, photoreceptor degeneration |
Williams et al. (2008) |
I1R activation |
Autophagy induction |
Cell line, zebrafish, mouse |
mHtt aggregation, photoreceptor degeneration, mHtt levels, motor phenotypes |
Williams et al. (2008), Rose et al. (2010)
|
L-type Ca2+ channel inhibition |
Autophagy induction |
Zebrafish |
mHtt aggregation, photoreceptor degeneration |
Williams et al. (2008) |
AMPK activation |
Autophagy induction |
Mouse |
Motor phenotypes, survival time |
Ma et al. (2007) |
Hsp40 overexpression |
Chaperone induction |
Yeast, in vitro
|
mHtt aggregation, mHtt fibril and oligomer formation |
Krobitsch and Lindquist (2000), Muchowski et al. (2000), Wacker et al. (2004)
|
Hsp70 overexpression |
Chaperone induction |
Yeast, in vitro, fly |
mHtt aggregation, mHtt fibril and oligomer formation, ocular degeneration |
Warrick et al. (1999), Krobitsch and Lindquist (2000), Muchowski et al. (2000), Wacker et al. (2004)
|
Hsp104 overexpression |
Chaperone induction |
Cell line, yeast, mouse |
Cell death, mHtt aggregation, mouse survival |
Carmichael et al. (2000), Krobitsch and Lindquist (2000), Vacher et al. (2005)
|
Hsp90 inhibition |
HSF1 and HSR activation |
Cell line, fly |
mHtt aggregation, photoreceptor degeneration |
Sittler et al. (2001), Fujikake et al. (2008)
|
HSF1 activation (Hsp90-independent) |
HSR activation |
Cell line, fly |
mHtt aggregation and levels, cell death, eye degeneration |
Neef et al. (2010) |
Parkin overexpression |
UPS induction |
Cell line |
PolyQ aggregation and levels |
Tsai et al. (2003) |
HRD1 overexpression |
UPS induction |
Cell line |
mHtt levels and aggregation, cell death |
Yang et al. (2007) |
PA28γ overexpression |
UPS induction |
Primary neuron |
mHtt levels, cell death |
Seo et al. (2007) |
CHIP overexpression |
UPS induction |
Cell line |
mHtt aggregation, cell death |
Jana et al. (2005) |