Table 3.
Pooled hazard ratios and 95% confidence intervals of quintiles of pre-diagnosis dietary fat intake among women diagnosed with breast cancer (n=8,580) in relation to breast cancer death (n=1,282) in the Nurses’ Health Study and the Nurses’ Health Study II.a
| Q1 | Q2 | Q3 | Q4 | Q5 | ||
|---|---|---|---|---|---|---|
|
| ||||||
| Hazard Ratio (95% Confidence Interval) | p-trend | |||||
|
|
||||||
| Total Fat | ||||||
| Model 1 | 1.00 | 1.12 (0.91, 1.38) | 1.13 (0.92, 1.38) | 1.10 (0.89, 1.34) | 0.97 (0.78, 1.19) | 0.62 |
| Model 2 | 1.00 | 1.05 (0.84, 1.32) | 1.16 (0.92, 1.44) | 1.08 (0.86, 1.35) | 0.97 (0.76, 1.24) | 0.85 |
| Saturated fat | ||||||
| Model 1 | 1.00 | 1.03 (0.83, 1.28) | 1.01 (0.80, 1.28) | 1.11 (0.86, 1.43) | 0.91 (0.66, 1.26) | 0.64 |
| Model 2 | 1.00 | 1.06 (0.83, 1.34) | 1.04 (0.81, 1.34) | 1.20 (0.91, 1.59) | 0.97 (0.68, 1.39) | 0.98 |
| Monounsaturated fat | ||||||
| Model 1 | 1.00 | 1.04 (0.83, 1.30) | 1.13 (0.89, 1.44) | 1.04 (0.79, 1.37) | 1.02 (0.72, 1.45) | 0.98 |
| Model 2 | 1.00 | 1.07 (0.84, 1.37) | 1.25 (0.96, 1.63) | 1.12 (0.83, 1.51) | 1.19 (0.81, 1.75) | 0.43 |
| Polyunsaturated fat | ||||||
| Model 1 | 1.00 | 1.07 (0.88, 1.30) | 1.02 (0.83, 1.25) | 1.01 (0.81, 1.25) | 0.98 (0.77, 1.23) | 0.70 |
| Model 2 | 1.00 | 1.17 (0.94, 1.45) | 0.96 (0.77, 1.21) | 1.11 (0.87, 1.41) | 1.08 (0.83, 1.40) | 0.73 |
| Trans fat | ||||||
| Model 1 | 1.00 | 1.00 (0.81, 1.23) | 0.92 (0.73, 1.14) | 0.88 (0.70, 1.11) | 0.82 (0.63, 1.08) | 0.09 |
| Model 2 | 1.00 | 0.99 (0.79, 1.25) | 0.90 (0.71, 1.15) | 0.86 (0.66, 1.11) | 0.76 (0.55, 1.04) | 0.05 |
| Long chain n-3 fatty acids | ||||||
| Model 1 | 1.00 | 0.99 (0.81, 1.21) | 1.07 (0.86, 1.33) | 1.20 (0.96, 1.51) | 1.08 (0.83, 1.40) | 0.41 |
| Model 2 | 1.00 | 1.00 (0.80, 1.24) | 1.16 (0.91, 1.48) | 1.27 (0.98, 1.63) | 1.16 (0.87, 1.55) | 0.25 |
| Animal fat | ||||||
| Model 1 | 1.00 | 0.95 (0.76, 1.17) | 1.03 (0.83, 1.27) | 1.06 (0.86, 1.31) | 0.92 (0.73, 1.16) | 0.63 |
| Model 2 | 1.00 | 1.02 (0.81, 1.29) | 1.09 (0.87, 1.37) | 1.05 (0.83, 1.33) | 1.02 (0.77, 1.35) | 0.90 |
| Vegetable fat | ||||||
| Model 1 | 1.00 | 0.89 (0.73, 1.09) | 1.02 (0.84, 1.25) | 1.01 (0.82, 1.24) | 0.82 (0.65, 1.03) | 0.23 |
| Model 2 | 1.00 | 0.97 (0.78, 1.21) | 1.06 (0.84, 1.33) | 1.04 (0.82, 1.31) | 0.85 (0.66, 1.10) | 0.34 |
| Cholesterol | ||||||
| Model 1 | 1.00 | 1.22 (0.99, 1.51) | 1.26 (1.02, 1.57) | 1.20 (0.96, 1.51) | 1.24 (0.97, 1.59) | 0.23 |
| Model 2 | 1.00 | 1.24 (0.98, 1.57) | 1.36 (1.07, 1.73) | 1.25 (0.97, 1.60) | 1.24 (0.94, 1.64) | 0.32 |
Women with stage IV breast cancer were excluded from this analysis. Exposure was quintiles of percent calories from fat.
Model 1: Stratified on calendar year and age in months and adjusted for the same variables in Table 2.
Model 2: Additionally adjusted for change in intake of that type of fat after diagnosis, tumor stage (I, II, III, missing), ER/PR status (ER+/PR+, ER+/PR−, ER−/PR−, other/missing), chemotherapy (yes, no, missing), hormone therapy (yes, no, missing), radiation therapy (yes, no, missing), and month of diagnosis.