Table 1.

Demographic and etiologic characteristics of osteosarcoma cases and controls.

Variable	Controls (n = 428)		Cases (n = 247)		P
	n	%	n
Sex
Male	265	61.9	154	62.3	0.934
Female	163	38.1	93	37.7
Age (yrs)
≤26	278	65.0	161	65.2	0.952
>26	150	35.0	86	34.8
Race
Han	279	65.2	159	64.4	0.555
Minority	149	34.8	88	35.6
Smoking status
No	398	93.0	231	93.5	0.792
Yes	30	7.0	16	6.5
Drinking status
No	402	93.9	233	94.3	0.829
Yes	26	6.1	14	5.7
Paget's disease
No	428	100.0	246	96.6	0.366
Yes	0	0.0	1	0.4
Trauma
No	411	96.0	228	92.3	0.038
Yes	17	4.0	19	7.7
Radiation exposure
No	415	97.0	236	95.5	0.339
Yes	13	3.0	11	4.5
PBBLb
No	428	100.0	246	96.6	0.366
Yes	0	0.0	1	0.4

^aThe mean ± S.D. ages were 26.38 ± 15.51 and 26.31 ± 14.16 for cases and controls, respectively.

^bPBBL refers to the preexisting benign bone lesions, including fibrous dysplasia, osteochondromatosis, and chondromatosis.